As Director of the NIH-funded Oregon BIRCWH K12 training program and AHRQ Patient Centered Outcomes Research K12, Dr. Guise has developed an infrastructure to promote career development of researchers. She has 20 years of federally-funded research. Her research portfolio includes characterizing and improving obstetric and pediatric patient safety in and out of hospitals; advancing information technology through development of electronic health records and decision aids; and filling the gap between evidence and patient experiences of health care. She enjoys working in cross-institutional and international collaboratives to advance scientific methods and get the best evidence into practice. She participated in major cross-CTSA NIH initiatives developing methodological guidance for patient and stakeholder engagement, pragmatic trials, and comparative effectiveness research and in her role as Director of the National Scientific Resource Center for the AHRQ Evidence-based Practice Centers Program, she leads and supports methods development and strategic planning for the U.S. Evidence-based Practice Centers (EPC) Program. She has studied and published papers with BIRCWH programs on mentoring and organizational infrastructure required to promote team science and recently chaired a panel for the BIRCWH on keys to a long and successful research career: lessons from experience and history. As a physician scientist herself, Dr Guise is particularly concerned about the future of physician scientists and was named director of a recently established office for the physician scientist in the OHSU School of Medicine.